Chemical modification from nucleosides to nucleic acid systems

Nucleosides, Nucleotides and Nucleic Acids

To cite this article: Krzysztof Komodziński, Zofia Gdaniec & Bohdan Skalski (2015) Photochemical Behavior of 2-Azidopurine Tri-O-Acetylribonucleoside in Aqueous Solution: Unprecedented Transformation into 1-(5′-O-Acetyl-β-D-Ribofuranosyl)-5-[(2-Oxo-1,3,5Oxadiazocan-4-Ylidene)Amino]-1H-Imidazole-4-Carbaldehyde, Nucleosides, Nucleotides and Nucleic Acids, 34:4, 235-245, DOI: 10.1080/15257770.2014...

Nucleosides, Nucleotides and Nucleic Acids

Drug–DNA Interaction Studies of Acridone-Based Derivatives Kuntebomanahalli Thimmaiah, Apoorva G. Ugarkar, Elvis F. Martis, Mushtaque S. Shaikh, Evans C. Coutinho & Mayur C. Yergeri To cite this article: Kuntebomanahalli Thimmaiah, Apoorva G. Ugarkar, Elvis F. Martis, Mushtaque S. Shaikh, Evans C. Coutinho & Mayur C. Yergeri (2015) Drug–DNA Interaction Studies of Acridone-Based Derivatives, Nuc...

Nucleosides, Nucleotides and Nucleic Acids

Chemical etiology of nucleic acid structure.

Systematic chemical studies indicate that the capability of Watson-Crick base-pairing is widespread among potentially natural nucleic acid alternatives taken from RNA's close structural neighborhood. A comparison of RNA and such alternatives with regard to chemical properties that are fundamental to the biological function of RNA provides chemical facts that may contain clues to RNA's origin.

Nucleic Acid Templated Reactions for Chemical Biology

Nucleic acid directed bioorthogonal reactions offer the fascinating opportunity to unveil and redirect a plethora of intracellular mechanisms. Nano- to picomolar amounts of specific RNA molecules serve as templates and catalyze the selective formation of molecules that 1) exert biological effects, or 2) provide measurable signals for RNA detection. Turnover of reactants on the template is a val...